Endocrine Abstracts

Hyperthyroid patients show an impaired response or even resistance to digoxin treatment.Objectives: 1. Are there any differences in the pharmacokinetics of a single oral dose of digoxin between hyperthyroid and euthyroid patients? 2. Does simultaneous administration of digoxin and methimazole or digoxin and acebutolol affect the pharmacokinetics of a single oral dose of dogoxin? 3. Does methimazole-induced euthyroidism change the pharmacokinetics of a si...

Introduction: Vitamin D, known mainly as a calcium-phosphorus homeostasis regulator, turned out to play also a significant role in the immune system modulation. Vitamin D deficiency has been reported in some autoimmune disorders. It is also suspected that polymorphisms of vitamin D-related genes comprise a risk factor for different autoimmune diseases. Therefore the aim of our study was to assess vitamin D receptor (VDR) gene FokI polymorphism in thyroid associated orbitopathy...

Introduction: Vitamin D is postulated to play a significant role in the immune system modulation and its deficiency has been reported in some autoimmune disorders. Polymorphisms of different vitamin D-related genes, among them vitamin D receptor gene (VDR), could either be a risk factor for autoimmune diseases. Therefore the aim of the study was to assess the association between VDR Cdx2 (rs11568820) polymorphism and autoimmune thyroid disease (AITD) among th...